Abstract
Background and Aims : Calcium deposition to the vascular smooth muscle matrix, or vascular calcification, makes vessels rigid and increases morbidity and mortality in patients with cardiovascular and renal diseases. Previously, we reported that histone deacetylase (HDAC) 1 prevents vascular calcification, whereas its E3 ligase, mouse double minute 2 homolog (MDM2), induces vascular calcification by repression of HDAC1. The regulatory mechanism for this action of MDM2 remained unclear. In the present study, we investigated whether MDM2-induced vascular calcification is dependent on the ubiquitination activity of MDM2 and determined the upstream regulator of MDM2.
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