Abstract
The relative levels of luteinizing hormone releasing factor (LRF) activity in hypothalami of lambs from 9.5 cm crown-rump (C-R) (day 55) to 49 cm C-R (day 148) of prenatal development and in neonates aged 14 to 18 days were determined by an in vitro system. Luteinizing hormone (LH) released from rat adenohypophyses in response to hypothalamic extracts was measured by a sensitive radioimmunoassay specific for murine LH. LRF activity was not detected in hypothalami of fetal lambs, but was readily measurable in hypothalami of neonates of both sexes; however, there was no significant difference between the levels in males and females. Because other studies suggest the existence of hypothalamic control of LH secretion prenatally, the failure to detect LRF activity in fetal hypothalami in the present investigation is attributed either to a loss of LRF activity from the tissue tested as a result of prolonged storage in an unextracted state, or to the possibility that LRF does not accumulate in the hypothalamus o...
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