Regulation of lipid metabolism by the major components of orange essential oil in high-fat diet mice

Abstract

Orange essential oil (OEO) is an important citrus by-product that has been utilized as a nutritional modulator. In the study, we investigated the effects of limonene, linalool, and decanal (the major components of OEO) on hepatic lipid composition and metabolism in high-fat diet (HFD) mice. The results showed that limonene, linalool and decanal treatments alleviated weight gain and dyslipidemia induced by HFD. In addition, compared to the HFD group, hepatic lipids were significantly altered in the treated groups, PIs, PEs and PGs screened as marker metabolites. Furthermore, we found that limonene, linalool and decanal accelerated the oxidation of fatty acids by stimulating of PPAR-α and CPT-1 expression. Therefore, our study can provide theoretical support for aromatics as nutritional regulators.