Abstract
Purpose: Synovial fibrosis, a hallmark pathological feature associated with osteoarthritis (OA), is characterized by excessive deposition of extracellular matrix (ECM). However, the exact mechanisms underlying the increased ECM production in the synovium are not well understood. We have previously shown that microRNA (miR)-27b-3p is increased in the synovial fluid of late-stage (Kellgren lawrence (KL) grade 3 & 4) compared to KL grade 1 & 2 radiographic knee OA patients. We also identified that miR-27b-3p was highly expressed in the OA synovial tissue compared to cartilage.
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