Regulation of innate receptor pathways by microRNAs

Abstract

The innate immune response provides the initial defense against infection. This is accomplished by families of pattern recognition receptors (PRRs) that bind to conserved molecules in bacteria, fungi and viruses. PRRs are finely regulated by elaborate mechanisms to ensure a beneficial outcome in response to foreign invaders. MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that are emerging as important regulators in immune responses at the post-transcriptional level, through the inhibition of translation, or by inducing mRNA degradation. It has been shown that miRNAs have unique expression profiles in cells of the innate immune systems and play pivotal roles in regulating the signal pathways of innate receptors, including Toll-like receptors, RIG-I-like receptors and Nod-like receptors. We have summarized the recent literature providing new insights into the regulation of innate receptor pathways by miRNAs.