Abstract
Spleen cells from mice immunized with different adjuvants are able to suppress secondary in vitro IgG plaque-forming cell (PFC) responses. The suppressive effect is mediated by Lyt-2-positive T cells. IgG subclasses are affected differentially depending on the number of T suppressor (T s) cells added in the assays. At low T s cell concentration IgG 2a and IgG 2b PFC responses are selectively inhibited. At higher T s cell concentration IgG 1 responses could also be completely inhibited, but IgA and IgM responses are not affected. Suppressor cells responsible for IgG 1, IgG 2a, and IgG 2b suppression are never found in the draining lymph nodes of adjuvant-immunized animals.
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