Regulation of IκB Kinase (IKK) Complex by IKKγ-dependent Phosphorylation of the T-loop and C Terminus of IKKβ

Ebrahim Zandi,Beth Schomer-Miller,Yung-Kang Lee,Tomoyasu Higashimoto

doi:10.1074/jbc.m513793200

Ebrahim Zandi, Beth Schomer-Miller + Show 2 more

Open Access

https://doi.org/10.1074/jbc.m513793200

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Abstract

Regulation of IκB Kinase (IKK) Complex by IKKγ-dependent Phosphorylation of the T-loop and C Terminus of IKKβ

Highlights

I␬Bs regulate the activity of the NF-␬B transcription factors
RNA interference data indicate that TRAF2 and TRAF6 are required for IKK activation after T cell receptor ligation [25]
IKK may be down-regulated by deubiquitinating proteases such as CYLD, which associate with IKK␥ and deubiquitinate TRAF2 and TRAF6 (29 –31)

Summary

Introduction

I␬Bs regulate the activity of the NF-␬B transcription factors. NF-␬Bs control the transcription of hundreds of genes involved in immunity, stress, and regulation of apoptosis and cellular proliferation. IKK complexes containing IKK␥ with either wild-type IKK␤ or IKK␤M10 were expressed in yeast and partially purified by gel filtration.

Results

Conclusion