Abstract
Radioimmunoassays for follicle stimulating hormone (FSH) and luteinizing hormone (LH) were used to determine the concentrations of these gonadotropins in sera from healthy men. No evidence of diurnal or other rhythmic variations in serum concentrations was found in samples obtained daily, 3 times a day, or hourly. Treatment of 3 subjects with 1.5 mg of ethinyl estradiol/day for 2–3 days resulted in a consistent fall in serum concentrations of both FSH and LH. Treatment of 3 subjects with 25 mg of testosterone propionate each day for 3 days resulted in a consistent fall in serum concentrations of LH. Treatment of 4 subjects with 200 mg of clomiphene citrate daily for 3 days resulted in a rise in serum concentrations of both FSH and LH.
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