Regulation of human A2A adenosine receptor conformational dynamics by endogenous phospholipids

Abstract

Endogenous phospholipids are widely recognized to regulate membrane protein structure and activity through specific protein-lipid interactions and by altering membrane bulk chemical and physical properties. Protein-lipid interactions are important regulators of G protein-coupled receptors (GPCRs), sensory membrane proteins that control many physiological processes and targets of over one-third of FDA-approved drugs. However, molecular mechanisms by which phospholipids regulate GPCRs are not well understood.