Abstract
Hypercholesterolemia is associated with an increased risk of coronary artery disease, such as atherosclerosis. The liver plays a central role in regulating cholesterol homeostasis. High fat diet has been shown to induce obesity and hyperlipidemia. Despite considerable advance in our understanding of cholesterol metabolism, the regulation of liver cholesterol biosynthesis in response to high fat diet feeding has not been fully addressed. The aim of the present study was to investigate mechanisms by which a high fat diet caused activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate-limiting enzyme, leading to increased cholesterol biosynthesis.
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