Abstract
The regulation of hematopoietic stem cell (HSC) fate decision, whether they keep quiescence, self-renew, or differentiate into blood lineage cells, is critical for maintaining the immune system throughout one’s lifetime. As HSCs are exposed to age-related stress, they gradually lose their self-renewal and regenerative capacity. Recently, many reports have implicated signaling pathways in the regulation of HSC fate determination and malignancies under aging stress or pathophysiological conditions. In this review, we focus on the current understanding of signaling pathways that regulate HSC fate including quiescence, self-renewal, and differentiation during aging, and additionally introduce pharmacological approaches to rescue defects of HSC fate determination or hematopoietic malignancies by kinase signaling pathways.
Highlights
Hematopoietic stem cells (HSCs) are quiescent and pluripotent cells that reside in bone marrow (BM)and continuously replenish blood cells throughout life [1]
The HSC pool is divided into two different subpopulations based on long-term reconstituting activity: long-term HSCs (LT-HSCs) and short-term HSCs (ST-HSCs), which can subsequently differentiate to multipotent progenitors (MPPs) that in turn differentiate into lymphoid or myeloid cells [2,3,4]
We have introduced many of the signaling pathways regulating the fate of HSCs including quiescence, self-renewal, and differentiation during aging, and the malignancy of HSCs
Summary
Hematopoietic stem cells (HSCs) are quiescent and pluripotent cells that reside in bone marrow (BM). HSCs can both self-renew and differentiate toward all blood lineages, and they maintain their homeostasis with low metabolic and cell cycle activity. In response to various signals, HSCs can be kept in quiescence, self-renew, or differentiate into lineage cells. These processes are regulated by various cellular signaling pathways, dysregulation of which results in defects of HSC function and hematopoiesis during aging. Elucidation of signaling pathways involved in HSC fate determination advances understanding of hematopoietic processes and may contribute to the development of efficient treatments for hematopoietic malignancies. 2 2of of 17 and may contribute to the development of efficient treatments for hematopoietic malignancies and and age-related immune disorders.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
