Abstract
1. 1. Glutamate is metabolized mainly by transamination to aspartate. 2. 2. Reductive deamination by GDH is found in 1/3 of all glutamate that disappeared. 3. 3. Glutamate transamination to alanine is negligible. 4. 4. NADH and 2-oxoglutarate concentrations involve a glutamate-stat by acting both on the GDH system and on the GOT-MDH coupled system: the extremely low equilibrium constants of these two systems support glutamate formation. 5. 5. Equilibrium constant of the GOT-MDH coupled system are 4.05 × 10 −5 at 25°C, pH 7.4. 6. 6. Oxaloacetate available, MDH competes with the respiratory chain for NADH. 7. 7. M.E. (NAD +) promoting malate oxidation contributes to NADH supply involved in glutamate metabolization control.
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