Abstract
Glucose uptake and glycolysis in the heart are increased during myocardial ischemia in order to provide an additional anaerobic source of ATP for the heart. This alteration in glucose metabolism constitutes an important contributing factor towards ischemic injury, and therefore it is important to understand how glucose uptake is controlled in the ischemic heart. There are primarily two glucose transporters which regulate glucose uptake into cardiac myocytes, GLUT1 and GLUT4. In the non-ischemic heart, insulin is only able to stimulate the translocation of GLUT4 to the sarcolemmal membrane, while both GLUT1 and GLUT4 translocation can occur following AMPK stimulation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
