Abstract
Understanding the regulation of antibody production and B-cell memory formation and function is core to finding new treatments for B-cell-derived cancers, antibody-mediated autoimmune disorders, and immunodeficiencies. Progression from a small number of antigen-specific B-cells to the production of a large number of antibody-secreting cells is tightly regulated. Although much progress has been made in revealing the transcriptional regulation of B-cell differentiation that occurs during humoral immune responses, there are still many questions that remain unanswered. Recent work on the expression and roles of histone modifiers in lymphocytes has begun to shed light on this additional level of regulation. This review will discuss the recent advancements in understanding how humoral immune responses, in particular germinal centers and memory cells, are modulated by histone modifiers.
Highlights
Pathogen clearance and formation of immunity requires the activation of B-cells and subsequent differentiation into antibodysecreting cells and memory cells
This review will discuss the limited information that is currently known about epigenetic regulators and their importance in the generation and maintenance of immune memory, focusing on the role of histone modifiers within the germinal center (GC)
CONCLUDING REMARKS Histone modifications are an important component of gene expression regulation
Summary
Pathogen clearance and formation of immunity requires the activation of B-cells and subsequent differentiation into antibodysecreting cells and memory cells. HISTONE MODIFICATION PATTERNS IN DIFFERENT B-CELL SUBSETS Germinal center B-cells and plasma cells have their own unique transcriptional program compared to naïve and memory B-cells [2, 18,19,20]. A large number of gene expression changes occur during differentiation of a naïve B-cell to GC to memory or plasma cell.
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