Abstract
Many constituents of serum and of the extracellular environment are essential for stimulation of cell growth and maintenance of differentiated function. Peptide growth factors form one subset of such components and epidermal growth factor (EGF) is one of the best-defined members of this class of growth regulatory substances. Many advances have been made in understanding mechanisms which underlie biological activities of EGF since it was first described by Stanley Cohen as a peptide present in nerve growth factor preparations that promoted early eyelid opening and tooth eruption in mice (1). Because physiological and cellular responses to EGF have been widely reviewed (2–6), this article emphasizes the role of EGF in regulating gene expression.KeywordsEpidermal Growth Factor ReceptorMutant Epidermal Growth Factor ReceptorEpidermal Growth Factor Receptor GeneSerum Response FactorGTPase Activate ProteinThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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