Abstract

Actin filaments are one of the main components of the eukaryotic cytoskeleton that regulate cellular architecture and mechanical properties. Dynamic regulation of actin filament size and organization is essential for the control of many physiological processes including cell adhesion, motility, cytokinesis and tissue morphogenesis. While previous studies have mostly focused on the length control of individual actin filaments, it remains poorly understood how actin filaments in a cell regulate heterogeneity in size using a limited set of monomeric building blocks and actin binding proteins (ABPs).

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