Abstract
Aims. In order to study the levels of matrix metlloproteinase-9, tissue inhibitor of metalloproteinase-1, intracardiac hemodynamics, frequency of acute cardiac aneurysm development in patients with Q-wave myocardial infarction after thrombolysis, 74 patients were examined.Methods and results. All participants underwent clinical and laboratory examination, echocardiography, determination of serum levels of matrix metlloproteinase-9 and tissue inhibitor of metalloproteinase-1.Conclusion. Patients, who got thrombolysis in 6 to 12 hours period, had excessive activation of the proteolysis system on the background of relative deficit of tissue inhibitor of metalloproteinase-1, the prevalence of dilatation and restrictive diastolic dysfunction, cardiac aneurysm was detected frequently and thrombogenic potential was higher.
Highlights
In order to study the levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, intracardiac hemodynamics, frequency of acute cardiac aneurysm development in patients with Q-wave myocardial infarction after thrombolysis, 74 patients were examined
Patients and methods 74 patients (43 males and 31 females, mean age – 61.2 ± 3.5 years) were examined. They were delivered to the intensive care unit of Municipal Institution «City Clinical Hospital of Emergency and Urgent Care of Zaporizhzhya» with a diagnosis of acute Q-wave myocardial infarction of anterior wall of left ventricle (LV)
Drug treatment was performed according to the order of Ministry of Public Health of Ukraine No436 from 03.07.2006 «Protocols of care for patients with Acute Coronary Syndrome with segment ST elevation (Q-wave myocardial infarction)
Summary
Regulation of extracellular matrix in patients with Q-wave myocardial infarction after thrombolytic therapy Zaporizhzhya State Medical University Key words: matrix metalloproteinase, myocardial infarction, heart aneurysm. In order to study the levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, intracardiac hemodynamics, frequency of acute cardiac aneurysm development in patients with Q-wave myocardial infarction after thrombolysis, 74 patients were examined.
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