Abstract
The assembly of the developing egg is a fascinating example of division of labor among oocytes and other tissues, with the coordination of activities in different tissues being achieved by hormones. Among nonoocyte tissues are (1) the follicle cells, which, under the influence of follicle-stimulating hormone (FSH), synthesize and release the sex steroids estrogen and progesterone; (2) the oviduct, which produces egg white proteins, coat proteins, or egg-sustaining fluids and whose activity is regulated by both steroid hormones; and (3) the liver, which, under the sole control of estrogen, provides the developing egg with yolk proteins, cholesterol, phospholipids, and lipoproteins. The participation of the oviduct and liver is particularly pronounced in nonmammalian species with free-living embryos, as in birds and amphibia.
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