Abstract
Organic fluorophores are indispensible in chemical/biological imaging. The conjugated fluorescent molecules simultaneously possessing highly tunable emission, high quantum yield in solvents of different polarities, and large Stokes shift are quite rare. Herein, we report a new category of fluorophores based on diarylated thieno[3,4-b]thiophenes efficiently synthesized by direct C–H arylation reaction. TbT-Fluors showed full-color-tunable emissions with large Stokes shifts. Intriguingly, the fluorescence quantum yields of TbT-Fluors are barely sensitive to solvent polarities, approaching 100%. Based on photophysical and theoretical investigations, we found that the enhanced oscillator strength of the S1-S0 transition and increased T2-S1 energy difference can sufficiently compensate the negative effect from the decreased energy gap and increased reorganization energy in dimethyl sulfoxide (DMSO). Bioimaging applications revealed that some TbT-Fluors can penetrate the cell membrane and are superior for imaging in terms of high photochemical stability and low cytotoxicity. Furthermore, TbT-PhF exhibits specific colocalization with mitochondria in living cells.
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