Abstract
The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoietic processes in the lymph gland. Focusing on blood cell maintenance and differentiation, this article summarizes the functions of several classic developmental signaling pathways for lymph gland growth and patterning, highlighting the important roles of developmental signaling during lymph gland development as well as Drosophila larval hematopoiesis.
Highlights
Developmental signaling pathways control the vast majority of cellular processes during animal development
In this review, focusing on the developmental process of lymph glands under normal conditions, we summarize the current understanding of the blood cell type, function, and patterning in the lymph gland, highlighting the physiological roles of several classic developmental signalings in the control of cell proliferation and lineage determination during Drosophila larval hematopoiesis
The Drosophila lymph gland has emerged as an excellent model system to study hematopoiesis
Summary
Developmental signaling pathways control the vast majority of cellular processes during animal development Several important signals, such as Wnt/Wingless (Wg), Hedgehog (Hh), and Notch, are repeatedly used to accurately, timely, and instruct tissue/organ development [1,2,3,4]. These pathways share similarities in the principles of signal transduction. In this review, focusing on the developmental process of lymph glands under normal conditions, we summarize the current understanding of the blood cell type, function, and patterning in the lymph gland, highlighting the physiological roles of several classic developmental signalings in the control of cell proliferation and lineage determination during Drosophila larval hematopoiesis
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