Abstract

The demand theory of gene regulation predicts that regulated cell-specific functions in high demand (i.e., high level of gene expression frequently required) are under the influence of a positive regulatory element whereas those in low demand (i.e., high level of gene expression not frequently required) are under the influence of a negative regulatory element. Furthermore, during differentiation, when the demand regimen for cell-specific functions changes, a switch in the regulatory mechanism itself is predicted. For the case in which a function is regulated in both demand regimens, the mode of regulation will switch from positive (high demand) to negative (low demand) or vice versa. These predictions are compared with published experimental evidence and found to be in good agreement.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.