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Abstract
During cytokinesis, the cytoplasm of the parental cell is divided into two daughter cells. This process begins with ingression of the cleavage furrow after sister chromatid separation, and is completed by severing of the narrow intercellular canal to release the two daughter cells. Successful cytokinesis requires the coordination of cytoskeletal, membrane trafficking and cell cycle regulatory pathways. Importantly, failure of cytokinesis can result in formation of genetically unstable tetraploid cells and can lead to tumourigenesis. Here, we describe recent progress in identifying the molecular mechanisms of cytokinesis in animal cells, and discuss how cytokinesis proteins can be targeted to potentially improve cancer therapy.
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