Abstract
The citrate synthases of Thiobacillus denitrificans and T. neapolitanus are inhibited by ∝-ketoglutarate but not by NADH. These characteristics are in accord with a purely biosynthetic role for the tricarboxylic acid (TCA) cycle in strict autotrophs. In contrast, the citrate synthases from two facultatively autotrophic thiobacilli, T. novellus and Thiobacillus A2, are not inhibited by ∝-ketoglutarate. The enzyme from Thiobacillus A2 resembles those of other Gram-negative bacteria in being inhibited by NADH whereas that from T. novellus is not. This may account, to some degree, for the better heterotrophic potential of Thiobacillus A2 compared with T. novellus .
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