Abstract
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel which is tightly regulated by phosphorylation and interactions with a macromolecular complex that mediates spatially localized signaling mechanisms. The complex may include scaffolds such as NHERF1, the adaptors ezrin and Receptor for Activated C Kinase (RACK1), and enzymes such as adenylyl cyclase, kinases, phosphatases, and phosphodiesterases. NHERF1 anchors CFTR to the actin cytoskeleton whereas RACK1 mediates its association with protein kinase C (PKC), however the relationships between these proteins remain poorly understood.
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