Abstract
Cyclic AMP (cAMP) plays a critical role in the heart because it regulates many physiological processes. The recent discovery of Epac (Exchange Protein directly Activated by cAMP), that functions independently of PKA, raises the question of its role in cardiac cells. There are two variants of Epac, Epac1 and Epac2, both are characterized by a regulatory domain which binds directly cAMP and a catalytic region containing an exchange factor motif for the Ras-like small GTPases Rap. Here, we investigated Epac isoform expression in human failing hearts and the functional effect of Epac in adult rat ventricular cardiomyocytes (ARVC).
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