Abstract
Abstract Background: Transplanting bone marrow derived mesenchymal stem cells(MSCs) have positive effects in treating many disease conditions including diabetes. To investigate the effects of systemic administration of
Highlights
Transplanting bone marrow derived mesenchymal stem cells(MSCs) have positive effects in treating many disease conditions including diabetes
The result of our study indicated that administration of allogenic MSCs in diabetic rats could reduce blood glucose, through regulating islet α and β cells proliferation
We found that the blood glucose levelin the MSCs treatment group was significantly lower than that of theuntreated control group at 11 days following MSCs injection, it was still higher than that of the normal level
Summary
Transplanting bone marrow derived mesenchymal stem cells(MSCs) have positive effects in treating many disease conditions including diabetes. To investigate the effects of systemic administration of MSCs on blood glucose changes, we studied the changes of islet β and α cellsin STZ-induced diabetic rats following systemic MSCs administration. Bone marrow derived mesenchymal stem cells (MSCs) are adult stem cells, with high proliferative potential and ability to differentiate into a variety of cell types [1]. Previous studies showed MSCs transplantation resulted in improvement of diabetes conditions, such as reducing blood glucose levels [3,4,5], partially because of the immunosuppressive effects of MSCs on T cells, increasing pancreatic islet β cell mass, preventing of β cell death [6] and promoting islet regeneration [7]. Understanding the effects of MSCs transplantation on islet cells will help to develop more effective treatment strategies
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