Abstract
Experiments with radioactive precursors showed that the terminal group of tetracyclines can originate by various pathways. Both malonylCoA originating by carboxylation of acetylCoA, and malonylCoA synthesized by alternative biosynthetic pathways, can be utilized. Radioactive malonate semiamide or its derivative was hydrolyzed to malonic acid during the fermentation and the acid was incorporated into tetracycline in the normal way. Of the other assumed precursors, U-14C-uracil, 1-14C-propionate, U-14C-alanine, 5-14C-glutamate were unspecifically incorporated into the terminal group of tetracycline. The incorporation of 4-14C-ethyl succinamate and 5-14C-ethyl glutaramate was negligible.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
