Abstract
We explore how ligand-receptor binding kinetics can be controlled by tethering the receptor to the end of a flexible polymer. The tether confines the diffusive motion of the receptor thus influencing the rate at which it captures ligands that are free in solution. We compute steady-state collision rates between ligand and receptor for this "tethered-capture" mechanism using a combination of analytic and numerical techniques. In doing so, we uncover a dimensionless control parameter, the "opacity," that determines under what conditions and to what extent a tether regulates the ligand-receptor collision rate. We compute the opacity for a number of different tethering scenarios that appear in biology and use these results to predict the affect of changing the length and flexibility of the tether on the rate at which ligands are captured from solution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
