Abstract
IN Aspergillus nidulans, mutations at more than 20 loci result in increased levels of two arginine catabolic enzymes, arginase and ornithine δ-transaminase (OTAse)1. The large number of genes involved either directly or indirectly in regulation of arginine catabolism makes interpretation of the regulatory mechanism(s) complicated. Some of these genes at least are concerned with catabolite repression rather than with control of specific induction and repression processes2. Here we present evidence that the synthesis of arginase and OTAse in A. nidulans is regulated in a positive fashion. Interrelations between the gene responsible for positive control and several other genes involved in the regulation of these enzymes were established. This enabled us to propose a model of the regulatory mechanism involving interaction between a specific positive and a nonspecific negative mode of regulation and providing a possible explanation of ammonium repression.
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