Abstract
The effects have been investigated of variations in the nutrient medium on the arginase ( l-arginine ureohydrolase, EC 3.5.3.1) activity of Chang's liver cells in tissue culture. Glucose is found to depress the arginase activity. Succinate as an additional carbohydrate source seems to enhance the effect of glucose. Cells grown in a medium with a low concentration of glucose have an arginase activity which depends on the concentration of arginine in the medium. In the discussion of the experimental results, several possible mechanisms which might be involved in the regulation of arginase activity have been examined. Among these are catabolite repression and substrate induction of synthesis of enzyme.
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