Abstract
Certain urodele amphibians and teleost fish display an elevated spectrum of organ regeneration with respect to mammals, with tissues like heart, retina, spinal cord, and appendages capable of impressive renewal after major injury. Zebrafish fins are complex structures containing bone, nerves, vasculature, connective tissue, and epidermis, and can achieve essentially perfect regeneration within 2 weeks of amputation. Here, we have utilized candidate gene approaches to dissect formation and function of the fin blastema, a proliferative mass of undifferentiated mesenchymal tissue that arises after ampuation and ultimately gives rise to the new structures of the regenerated appendage.
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