Abstract
We have studied the effect of the sex hormone estrogen on adrenergic response and receptors. The threshold dose of norepinephrine necessary to stimulate α-adrenergic contraction of rabbit uterus in vitro was decreased 10-fold by estrogen treatment. Myometrial α-adrenergic receptors quantitated with 3H dihydroergocryptine increased in parallel with increased adrenergic sensitivity, being 3-fold greater in estrogen-treated than in untreated or ovariectomized rabbits. In contrast, rabbit platelet α-adrenergic binding sites were decreased 40% by estrogen treatment. Thus estrogen treatment increased α-adrenergic response and receptors in uterus while decreasing α-adrenergic receptors in platelets from the same animal. Modulation of α-adrenergic receptors by estrogen provides a mechanism by which estrogens may modify adrenergic response.
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