Abstract
Publisher Summary This chapter describes adherens type junctions (AJ) modulation through changes in the level of expression of junctional components and explains that this modulation has a dramatic effect not only on cell structure, but also on cell motility and the tumorigenic ability of cells. Tyrosine phosphorylation of AJ proteins has been proposed to be a major mechanism in the signal transduction based on studies showing abundant tyrosine phosphorylation-dephosphorylation activity in AJ of both normal and transformed cells. The assembly of AJ apparently proceeds through an initial binding of the transmembrane contact receptor to its extracellular ligand (an ECM protein sequence, or a homologous cell adhesion (CAM) receptor). To determine the role of changes in the expression of AJ proteins in cell function, 3T3 cells are transfected with a full-length chicken vinculin cDNA construct and clones expressing stably different levels of the transgene were isolated.
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