Abstract
Regulation of acetylcholine receptor (AChR) gene expression was analyzed in α-bungarotoxin (α-BTX) treated rats. A reduction in available 125l-α-BTX binding sites was accompanied by an increase in the various AChR transcripts. The increase in the AChR α-, β- c- and δ-subunit mRNAs was similar to that observed in rats with experimental autoimmune myasthenia gravis (EAMG). Unlike in EAMG, the γ-subunit transcripts reappeared following α-BTX treatment. The quantitative differences in the levels of AChR transcripts between α-BTX treatment and EAMG on one hand and denervation on the other hand, support the notion that the regulation of AChR gene expression is controlled by muscle activity and by neuronal factors as well. We also demonstrate in this report that myogenin transcripts increase following α-BTX treatment as well as following denervation, whereas MyoD1 transcripts remain stable.
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