Regulation mechanism of nanobiointerfaces in amyloid peptide assembly and aggregation structures

Abstract

In this review, we try to reflect the recent progress on assembly structures, aggregation behaviors and the cytotoxicity of beta amyloid (Aβ) peptides, which are closely related to the pathogenesis of Alzheimer’s disease (AD). Based on these studies, the progress on the regulation mechanism of various nanobiointerfaces in amyloid peptide assembly and aggregation structures is reviewed and discussed, especially the interaction patterns and mechanisms between Aβ peptides and nanomaterials on the molecule level. These progresses could help to deepen the insights of the complex interactions between amyloid peptides and modulators. To study Aβ peptide conformation, assembly mechanism and aggregation process, developing new efficient nanobiointerface modulators is of great importance for the therapeutic strategy evolution.