Regulation der Proteostase – ein Fokus auf das Ubiquitin-Proteasomen-System

Abstract

Regulated proteolysis by the ubiquitin proteasome system (UPS) is vital for cells to preserve protein homeostasis (proteostasis). Proteotoxic stress by radical production can severely challenge proteostasis closely interconnecting redox with protein homeostasis. To counteract proteo - toxicity the capacity of the UPS is adjusted by differential expression of UPS factors and proteasome isoforms. Faulty regulation or proteasome impairment that cause an interferon response are hallmarks of many diseases and will be discussed.