Regulation der endosomalen und lysosomalen Biogenese

Abstract

Eukaryotic cells use the endocytic pathway to downregulate cell surface receptors or to take up nutrients from the outside, which are finally degraded in the lysosome. The machinery to degrade these components is also transported to lysosomes. Both pathways merge at the endosome, an organelle that undergoes massive membrane remodelling to remove proteins from its surface. Within this review, we will summarize our insights and approaches to unravel molecular mechanism of endosomal and lysosomal biogenesis.