Regulation, Aufbau und Funktion einer bakteriellen Nanomaschine

Abstract

The bacterial flagellum is a molecular nanomachine used for locomotion. In Salmonella, the assembly of the flagellum is a highly coordinated and regulated process. On top of a complex regulatory network resides the flagellar master operon flhDC. Many environmental signals are integrated on the level of flhDC expression, including transcriptional cross talk between the virulence and flagellar systems that contributes to the correct spatiotemporal expression of the different virulence factors during the infection process.