Abstract
Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.
Highlights
Understanding the molecular pathogenesis of Parkinson’s disease (PD) is a priority area in biomedical research
The PD enzymes discussed in this Research Topic were discovered either in genetic linkage or genetic association studies or in biological studies revealing a strong functional link with one of the PD proteins
PD enzymes are the ATPase ATP13A2 encoded by a gene at the PARK9 locus, several GTPases, including the small GTPase RAB7L1, and leucinerich repeat kinase 2 (LRRK2) which functions as a kinase and GTPase (Greggio, 2012; Taymans, 2012)
Summary
Understanding the molecular pathogenesis of Parkinson’s disease (PD) is a priority area in biomedical research. A number of PD proteins have enzymatic functions, including kinase, GTPase or ATPase activity. As enzymes are often key elements in the regulation of cellular signaling networks, they themselves or additional pathway components might provide new therapeutic targets for disease modifying therapies.
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