Abstract
The cardiac neural crest cells (NCCs), also known as circumpharyngeal NCCs, make an essential contribution to cardiovascular development in vertebrates. These cells delaminate from the developing neural tube to migrate into the pharyngeal arches (PAs) of the embryo, where they induce the remodeling of the pharyngeal arch arteries (PAAs) into the great vessels that distribute blood from the heart into the lung and systemic vasculature. A subset of cardiac NCCs continues to migrate into the cardiac outflow tract (OFT) to induce its septation into the arterial and pulmonary trunks that connect to the remodeled PAAs. Owing to their essential role in cardiovascular development, cardiac NCC defects cause congenital heart disease. In this article, we describe current knowledge of the molecular and cellular mechanisms that underlie cardiac NCC function.
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