Regulating Type H Vessel Formation and Bone Metabolism via Bone‐Targeting Oral Micro/Nano‐Hydrogel Microspheres to Prevent Bone Loss (Adv. Sci. 15/2023)

Abstract

Osteoporosis A pH-responsive shell-core structured micro/nano-hydrogel microspheres construct via gas microfluidics and ionic cross-linking technique. The microspheres can achieve oral delivery, intragastric protection, intestinal slow/controlled release, and active targeting to bone tissue. This novel oral microspheres can simultaneously accelerate intraosseous vascularization and decrease bone resorption, offering a brand-new approach to prevent postmenopausal osteoporosis. More details can be found in article number 2207381 by Wenguo Cui, Peng Jia, Youjia Xu, and co-workers.