Abstract
This paper presents a new approach in the field of controlled drug delivery systems using a novel quantum dot (QD). We developed a system for polymeric microencapsulated drugs which is conjugated to near infrared (NIR) absorbing quantum dots and tested the feasibility of burst release of a model drug, heparin, from microcapsules triggered by irradiation. We have shown the burst release of heparin from microcapsules can be achieved by irradiation. This system is designed to externally modulate drug release in response to physiological needs by control of the intensity and period of irradiation. These results suggest that QD can be a key component to be used for triggering the release of drugs for various clinical applications. We further investigated the heparin incorporation into and release from decellularized blood vessels for potential application of functionalized heparin for vascular graft engineering.
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