Abstract
Most general models put forward to explain the molecular basis of differentiation invoke either the amplification of specific genes, their transcriptional activation, some form of post-transcriptional control, or a combination of these mechanisms. We wished to distinguish between these experimentally and have selected two models for this purpose, erythropoiesis and immunogenesis. Both are derived from the hematopoietic system. Erythropoiesis, as observed in the adult, represents a late stage in the process of differentiation. This process is continuous during the lifetime of the individual. Protein synthesis during the penultimate stage in the development of the erythrocyte, the reticulocyte, involves the almost exclusive synthesis of globin, providing a convenient biochemical marker for the isolation of a specific mRNA and gene product. Immunogenesis, on the other hand, appears to be a far more complex process. An especially intriguing and unique feature of the immunogenic response is the necessity of accounting, in genetic terms...
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