Abstract
BackgroundTill date, no studies have investigated the effects of cardiovascular health on the cardioprotective benefits of fish oil supplementation in people with type 2 diabetes (T2D). The utility of fish oil in reducing the risk of cardiovascular disease (CVD) mortality in people with diabetes remains unclear and inconsistent. ObjectiveTo investigate the potential modifying effect of cardiovascular health (CVH) level, as assessed using the Life’s Essential 8 (LE8) score, on the association between regular fish oil supplement use and CVD mortality in middle-aged and older people with T2D. MethodsParticipants with T2D in the UK Biobank were included. CVH level was categorized by the mean LE8 score (55 points). Multivariable-adjusted Cox models were used to evaluate the longitudinal association between regular use of fish oil supplements and CVD mortality. We performed stratified analysis across different CVH levels, and tested for potential interaction between fish oil supplement use and CVH level. ResultsThe analysis included 19,003 participants (mean age 59.9±6.9 years, 36.1% women), of whom 39.6% were regular users of fish oil supplements. During a median follow-up of 13.7 years, regular use of fish oil supplements was significantly associated with a lower risk of CVD mortality among participants with better CVH (i.e., LE8 score ≥55 points; hazard ratio [HR]=0.65, 95% confidence interval [CI] 0.51–0.84, P = 0.001), but not among those with poorer CVH (i.e., LE8 score <55 points; HR=1.02, 95% CI 0.83–1.25, P=0.867). The interaction between the use of fish oil supplements and CVH level on CVD mortality was significant (P=0.018). ConclusionsMiddle-aged and older T2D individuals with a relatively low baseline CVH level may not obtain cardiovascular benefits from fish oil supplements. Our findings highlight the importance of promoting multimodal lifestyle interventions to improve survival outcomes of people with T2D.
Published Version
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