Abstract
In the current study, the synergistic effects of a regular treadmill exercise and nicaraven-loaded nanocomposite hydrogel was investigated in a rat model of muscle injury. In vitro studies were used to characterize the composite hydrogel In vitro. In vivo study was performed in a rat model of muscle injury. Study showed that the regular treadmill exercise and nicaraven-loaded nanocomposite hydrogel improved the muscle injury repair by reducing muscle atrophy, decreasing the fibrosis tissue, and augmenting the expression levels of VEGF and b-FGF genes.
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