Abstract
ABSTRACTCross‐sectional and interventional studies suggest that high‐intensity strength and impact‐type training provide a powerful osteogenic stimulus even in old age. However, longitudinal evidence on the ability of high‐intensity training to attenuate age‐related bone deterioration is currently lacking. This follow‐up study assessed the role of continued strength and sprint training on bone aging in 40‐ to 85‐year‐old male sprinters (n = 69) with a long‐term training background. Peripheral quantitative computed tomography (pQCT)‐derived bone structural, strength, and densitometric parameters of the distal tibia and tibia midshaft were assessed at baseline and 10 years later. The groups of well‐trained (actively competing, sprint training including strength training ≥2 times/week; n = 36) and less‐trained (<2 times/week, no strength training, switched to endurance training; n = 33) athletes were formed according to self‐reports at follow‐up. Longitudinal changes in bone traits in the two groups were examined using linear mixed models. Over the 10‐year period, group‐by‐time interactions were found for distal tibia total bone mineral content (BMC), trabecular volumetric bone mineral density (vBMD), and compressive strength index, and for mid‐tibia cortical cross‐sectional area, medullary area, total BMC, and BMC at the anterior and posterior sites (polar mass distribution analysis) (p < 0.05). These interactions reflected maintained (distal tibia) or improved (mid‐tibia) bone properties in the well‐trained and decreased bone properties in the less‐trained athletes over the 10‐year period. Depending on the bone variable, the difference in change in favor of the well‐trained group ranged from 2% to 5%. The greatest differences were found in distal tibia trabecular vBMD and mid‐tibia posterior BMC, which remained significant (p < 0.05) after adjustment for multiple testing. In conclusion, our longitudinal findings indicate that continued strength and sprint training is associated with maintained or even improved tibial properties in middle‐aged and older male sprint athletes, suggesting that regular, intensive exercise counteracts bone aging. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Highlights
Low back pain (LBP) is the leading cause of activity limitation and work absence as a common health problem. 90% of LBP is nonspecific LBP, its origins and underlying mechanisms remain unclear.METHODS: The lumbar spine instability (LSI) and aging mouse model were established
Incident falls over three years were determined through telephone interviews every four months.Results: A higher MEDI-LITE score, indicating greater adherence to Mediterranean diet, was associated with higher appendicular lean mass adjusted for body mass index (ALMBMI) (β: 0.004 kg/kg/m2; 95% confidence interval (95% CI): 0.000, 0.008), and lower serum interleukin-7 (IL-7) (β: -0.017 pg/mL; 95% CI: -0.031, -0.003), and incident falls rates (IRR: 0.94; 95% CI: 0.89, 0.99)
We have shown that histone deacetylase (HDAC) inhibitors stimulate leukemia inhibitory factor receptor (LIFR) and, in combination with bisphosphonates, promote dormancy and prevent tumor-induced osteolysis in mouse models of bone colonization
Summary
Low back pain (LBP) is the leading cause of activity limitation and work absence as a common health problem. 90% of LBP is nonspecific LBP, its origins and underlying mechanisms remain unclear.METHODS: The lumbar spine instability (LSI) and aging mouse model were established. The major criteria including BCC and KCOT are often not evident until the childhood, the radiological manifestations of various skeletal abnormalities may contribute to make early diagnosis Rib anomalies such as bifid ribs, whose overall prevalence is estimated lower than 3% in general population, are common with high specificity in Gorlin syndrome.Objectives: The aim of this study was to verify the usefulness of occasional chest X-ray to detect skeletal abnormalities in pediatric patients with Gorlin syndrome.Methods: We retrospectively assessed the chest X-ray films of Gorlin syndrome patients aged under year old who have been followed at Osaka University Medical and/ or Dental Hospital since 2001.Results: Six patients (2 males and 4 females) were analyzed. Conclusions: Our research will provide new knowledge on the muscle-bone unit in severe obesity and T2D and inform future multimodal intervention studies to enhance muscle and bone health and prevent falls and fractures in these high-risk populations
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