Regression of the malignant aspect of intraepithelial neoplasias following an LH—RH agonist treatment and detection of human papillomavirus by molecular hybridization

Abstract

Patients presenting genital intraepithelial neoplasia and/or flat condyloma were treated with DTrp6-LH-RH (triptorelin) to induce a transitory suppression of estrogens. This treatment led in some cases to a complete clinical and histological regression accompanied by a disappearance of human papillomavirus sequences as detected by molecular hybridization.