Abstract
1. 1. Vibrio cholerae neuraminidase (VCN) injected directly into spontaneous mammary adenocarcinomas will induce a slowing of tumor growth. 2. 2. BCG will induce a similar regressive effect. 3. 3. The combined intratumor injections with BCG and VCN will induce the total regression of some spontaneous mammary adenocarcinomas. By analogy with the effect of these agents in syngeneic transplanted tumors, the effect can be considered to be immunological. 4. 4. Additional mammary adenocarcinomas will develop in mice with regressing tumors possibly because the immunity induced by the intratumor injections of VCN and/or BCG is not directed to the MTV antigen but rather to weaker specific antigens on the treated tumor.
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