Abstract
Regression of Murine Ehrlich Ascites Carcinoma Using Tumor-Targeting Salmonella VNP20009 - Comparison with the Effect of the Anticancer Drug Doxorubicin
Highlights
Resistance to conventional anticancer therapies in patients with advanced solid tumors [Patyar et al, 2010]– in addition to the side effects that patients experience from conventional chemotherapy such as nausea, vomiting, hair loss and sometimes bone marrow suppression– have prompted the need of alternative cancer therapies
Since hypoxia is a common characteristic of all tumors, which adversely affects the prognosis of cancer patients, targeting the hypoxic regions of tumors may increase the effectiveness of cancer treatment [Lee et al, 2005]
Since hypoxia is a common characteristic of human tumors, which adversely affects the prognosis of cancer patients, targeting the hypoxic regions of tumors is believed to increase the effectiveness of cancer therapy (Lee et al, 2005)
Summary
Resistance to conventional anticancer therapies in patients with advanced solid tumors [Patyar et al, 2010]– in addition to the side effects that patients experience from conventional chemotherapy such as nausea, vomiting, hair loss and sometimes bone marrow suppression– have prompted the need of alternative cancer therapies. The aim of research in the cancer field is selectively targeting and destroying malignant cells and Advances in Cancer: Research & Treatment 2 preventing their spread This goal has long remained elusive in large because of the extreme genetic and phenotypic variability of most tumors. S. typhimurium is a facultative anaerobe, (i.e., it can grow in aerobic and anaerobic conditions), it can selectively grow and preferentially replicate in tumor tissue, achieve tumor to normal tissue ratios in excess of 1,000 to 1 and result in reduced tumor growth [Pawelek et al, 1997] It can be engineered in the laboratory to express foreign genes as well as to attenuate its pathogenicity [Rosenberg et al, 2002]. Several studies indicated the safe use of such a strain that does not induce septic shock during infection in animal models, and yet retains its tumortargeting capability. Jia et al (2005)
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