Abstract
We conducted in this paper a regression analysis of factors associated with acute radiation pneumonia due to radiation therapy for lung cancer utilizing cluster analysis to explore the predictive effects of clinical and dosimetry factors on grade ≥2 radiation pneumonia due to radiation therapy for lung cancer and to further refine the effect of the ratio of the volume of the primary foci to the volume of the lung lobes in which they are located on radiation pneumonia, to refine the factors that are clinically effective in predicting the occurrence of grade ≥2 radiation pneumonia. This will provide a basis for better guiding lung cancer radiation therapy, reducing the occurrence of grade ≥2 radiation pneumonia, and improving the safety of radiotherapy. Based on the characteristics of the selected surveillance data, the experimental simulation of the factors of acute radiation pneumonia due to lung cancer radiation therapy was performed based on three signal detection methods using fuzzy mean clustering algorithm with drug names as the target and adverse drug reactions as the characteristics, and the drugs were classified into three categories. The method was then designed and used to determine the classification correctness evaluation function as the best signal detection method. The factor classification and risk feature identification of acute radiation pneumonia due to radiation therapy for lung cancer based on ADR were achieved by using cluster analysis and feature extraction techniques, which provided a referenceable method for establishing the factor classification mechanism of acute radiation pneumonia due to radiation therapy for lung cancer and a new idea for reuse of ADR surveillance report data resources.
Highlights
Lung cancer, known as primary bronchopulmonary cancer, is a malignant tumour that occurs mainly in bronchial mucosal epithelial cells, with a few occurring in alveolar tissue
Taking reasonable measures to reduce the incidence of acute radiation pneumonia after radiotherapy for lung cancer patients is an important research topic for clinical workers, which becomes a major clinical complication. e occurrence of acute radiation pneumonia will hinder normal treatment, leading to the inability to increase the radiation dose, the clinical treatment effect is very poor, and the patient’s quality of life is not ideal. is study aims to investigate the risk factors associated with acute radiation pneumonia in lung cancer patients after radiotherapy and to guide clinicians to take reasonable treatment measures to prevent the occurrence of acute radiation pneumonia according to the actual situation of patients, to improve the clinical effect of lung cancer radiotherapy and reduce the risk of radiation pneumonia
Many clinical factors have been reported to influence the development of radiation pneumonia, including age, gender, smoking history, and history of chronic obstructive pulmonary disease (COPD)
Summary
Known as primary bronchopulmonary cancer, is a malignant tumour that occurs mainly in bronchial mucosal epithelial cells, with a few occurring in alveolar tissue. The incidence of acute radiation pneumonia after radiotherapy for lung cancer patients is relatively high, which affects the effect of radiotherapy and increases the incidence of complications and increases the risk of radiotherapy. Taking reasonable measures to reduce the incidence of acute radiation pneumonia after radiotherapy for lung cancer patients is an important research topic for clinical workers, which becomes a major clinical complication. E occurrence of acute radiation pneumonia will hinder normal treatment, leading to the inability to increase the radiation dose, the clinical treatment effect is very poor, and the patient’s quality of life is not ideal. It is important to improve the clinical effect of radiotherapy and reduce the occurrence of complications
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